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25.56 Dermal nevus: focal calcification and even bone formation are not uncommon and usually represent a destroyed hair follicle

Calculations of key parameters of the mitochondrial function were performed, consisting of basal respiration (BR, OCR initial OCR rot/AA ), ATP production (ATP, OCR initial - OCR oligo ), proton leak (PL, OCR oligo OCR rot/AA ), maximal respiration (MR, OCR FCCP OCR rot/AA ), spare respiratory capacity (SRC, OCR FCCP - OCR initial ), spare respiratory capacity [%] (SRCP, MR/BR*100), non-mitochondrial respiration rate (NMRR, OCR rot/AA ), and coupling efficiency [%] (CE, ATP/BR*100)

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But, NMN is unable to function as described above in GPX4-knockdown keratinocytes, suggesting that the mechanism of ferroptosis resistance exerted by NMN is still reliant on GPX4 (Figure 6)

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